RESPIT - Regionally-specific immunotherapy, the practical alternative to allergy testing
RESPIT offers significant advantages over traditional allergy test-based immunotherapy. By including a cross-reacting allergen representative of the most important aeroallergen groups, RESPIT formulations cover the allergens most commonly implicated in canine atopic dermatitis for a given region.
- Effective allergy relief, without allergy testing. In a double-blinded trial, 76% of dogs responded to a standardized allergy vaccine that was not formulated on the basis of allergy test results.1 Intradermal test-based immunotherapy did not provide a significant advantage in terms of response.
- Since introducing RESPIT at SkinVet℠ Clinic, Jon Plant, DVM, DACVD, has monitored the response of each patient using a validated pruritus severity scale. The median pruritus score has dropped from 8 ("severe") to 2 ("very mild") after 70 days. Seventy-five percent of dogs have had a score reduction of 50% or more, a response rate on par with most reports of allergy test-based immunotherapy.
- Regionally-specific stock formulations are based on the most common and severe allergens in your area, not tests of questionable accuracy.2,3
- No more false negative allergy tests that frustrate you and your clients
- No more allergy tests that are positive to nearly everything and don't aid your selection of allergens.
- A lower allergen concentration (10,000 PNU/ml) befitting dogs and cats.
- Formulations take advantage of shared antigens and allergen cross-reactivity.
- A simplified, weekly administration schedule encourages owner compliance. High client acceptance and satisfaction.
- No need to wait weeks for a custom order. Keep RESPIT in stock and start immunotherapy right away.
- Manufactured in a USDA-licensed facility.
- Allows you to offer advanced, cost-effective allergy therapy in house.
LINKS TO REFERENCES
- Immunotherapy 101:Suggestions for veterinarians prescribing RESPIT™ for atopic dermatitis.
- Garfield study: Non-specific Immunotherapy This groundbreaking study demonstrated that immunotherapy with a standardized allergen mixture resulted in good to excellent response in 76% of atopic dogs.
- Codner study: Hyposensitization with Irrelevant AntigensImmunotherapy of normal greyhounds did not induce clinical signs of allergy.
- Weber review: Guidelines for Using Pollen Cross-Reactivity in Formulating ImmunotherapyA leading expert on allergen-cross reactivity provides some pearls on immunotherapy formulation.
- Ferrer-Canals: Reliability of Intradermal TestingThe repeatability and reproducibility of intradermal allergy testing was found to be lower than expected.
- Hill: A validated canine pruritus severity scale you can use in your practice.The owner makes a mark on Page 1, you measure with Page 2.
1. Garfield R. Injection immunotherapy in the treatment of canine atopic dermatitis: comparison of 3 hyposensitization protocols. 8th Annual Members Meeting of the American Academy of Veterinary Dermatology & the American College of Veterinary Dermatology. 1992. p. 7-8.
2. Ferrer-Canals G, Plant JD, Beale KM, Fadok V. Reliability of intradermal allergy tests in dogs with atopic dermatitis. Veterinary Dermatology. 2009; 20(3): 228.
3. DeBoer DJ, Hillier A. The ACVD task force on canine atopic dermatitis (XVI): laboratory evaluation of dogs with atopic dermatitis with serum-based "allergy" tests. Vet Immunol Immunopathol. 2001; 81(3-4): 277-87.